Skin Changes

    Skin changes on a knee icon

    For many people, the first signs of PVD begin slowly and irregularly. You may feel discomfort like fatigue and cramping in your legs and feet however there are several other symptoms associated with PVD including changes to the skin. The skin of the legs, ankles and feet may exhibit changes that can include any one or combination of the following: color changes, eczema, temperature changes, thickening of the skin, itching, open wounds and others.

    Symptom Details


    Arterial conditions, such as peripheral artery disease (PAD) and critical limb ischemia (CLI), and venous conditions, such as deep venous disease (DVD) and superficial venous insufficiency (SVI) can produce notable changes in the skin, especially on the legs and feet.


    Changes in the texture and color of the skin are a result of poor circulation in the arteries and veins.2,3,4


    When the circulation is compromised blood flow is decreased resulting in increased pressure in the vessels, leading to inflammation of the skin on one or both legs. The resulting inflammation may cause the skin to become leathery, itchy or reddish.1 Without treatment, increased swelling and skin inflammation due to poor circulation of blood can lead to serious complications such as rash, sores that are open as well as other ulcerations.5 Venous insufficiencies (DVI) can lead to stasis dermatitis which causes itching, scaling, hyperpigmentation, and sometimes ulceration.7 These are serious conditions that require prompt diagnosis and treatment. It is important you take the step and seek help from your doctor if you notice changes in your skin.


    Skin changes to your feet or legs can be a sign of several conditions such as PAD, DVD or SVI. The progressive conditions may start out with mild symptoms but with time, may lead to more moderate to severe symptoms.


    • Arterial conditions may produce poor nail growth on the toes
    • When blood pools around the extremities, it may lead to increased warmth around the affected leg
    • The skin may become dry and itchy
    • Skin feeling cool to the touch


    • There may be decreased hair growth on the legs as tissue begins to die
    • The skin can become pigmented and thick (lipodermatosclerosis) and easily break down
    • As venous disease progresses, there may be increased swelling, pressure and redness


    • Ulcerations in the ankles or calves may occur, as the skin breaks down and are slow to heal
    • Arterial conditions such as CLI may lead to ulcers on the feet and toes and eventually to black toes
    • Gangrene may develop and is a sign that tissue has died because of lack of blood flow



    When PVD causes skin changes it is a direct result of poor circulation. Trauma or surgery can also cause injury to an artery or vein resulting in skin changes.


    There are a number of other diseases and conditions not related to PVD that can exhibit skin changes. Only your doctor can pinpoint the cause of your skin changes.

    Risk Factors

    Foot with risk factor veins icon

    There are many risk factors that may predispose a person to developing skin changes due to PVD.


    In addition to vascular causes, other risk factors include:1


    • Age can be a risk factor for developing skin changes as poor circulation commonly develops in adults over 60 years of age
    • Previous trauma or injury can impair the body’s ability to move blood and can lead to skin changes
    • Gender can play a role as women are twice as likely to develop the condition than men
    • Multiple pregnancies can put pressure on a woman’s pelvic area and veins, resulting in skin changes in the lower extremities
    • Lifestyle can play a role, as standing for long periods of time and lack of exercise can reduce the body’s ability to circulate blood
    • Other medical conditions such as obesity and being overweight can increase the likelihood of developing skin changes due to increased pressure on the veins. High blood pressure and diabetes can also play a role in developing PVD and the resulting skin changes.

    What to Look For

    Skin Changes


    • The skin can become dry, cracked and leathery
    • The skin may feel itchy and irritated
    • Hyperpigmentation may develop as the skin lacks proper blood flow and oxygen
    • Redness may be present due to swelling
    • Eczema or rash
    • If the condition has progressed to severe stages, black toes or gangrene may be present
    • Poor nail growth
    • Reduced hair growth on the legs
    • Lack of pulse or weak pulse
    • Skin feels cool to the touch
    • Sores on the legs or feet that may also bleed and are either slow to heal or non-healing.
    • If the sores seep pus and have a bad odor, it may be an indication of an infection, which requires prompt medical attention

    Associated Symptoms

    Varicose Veins

    Varicose veins can become inflamed when the pooling of blood results in pressure on the vein walls resulting in redness, swelling, and a diffuse pain.


    Blood pooling in the legs creates pressure on the valves of the veins and damages the capillaries (small blood vessels) and leads to swelling.

    Non-Healing Wounds

    Ulcers can develop on both the legs and the feet. Ulcers which are above the ankle are usually a result of severe venous disease; the skin breaks down over time and wounds develop. Wounds that won’t heal or are slow to heal on the lower ankle and foot and a result of CLI, where the arteries are unable to bring oxygen rich blood to the foot and the tissues begin to die.

    When to See a Doctor


    Skin changes and discoloration may be a sign of a condition, such as PAD and DVD, which progresses if not treated properly. Other conditions such as CLI may produce skin changes that require prompt medical attention right away.


    Talk to your doctor if you are concerned about skin changes. In the case of ulcerations, gangrene or black toes, see your doctor immediately.

    Helpful Resources

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    PVD Doctor
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    Get helpful tips and advice on how to talk to your doctor about a PVD screening.

    Third-Party Resources



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    1. “Statsis Dermatitis.” American Academy of Dermatology. 2017.

    2. “Peripheral Vascular Disease.” John Hopkins Medicine. n.d.

    3. “What are the signs and symptoms of Peripheral Artery Disease?” National Institutes of Health. U.S. Department of Health and Human Services. n.d.

    4. Simon et al. “Peripheral artery disease and intermittent claudication.” University of Maryland Medical Center. May 24, 2012.

    5. Eberhardt et al. “Chronic Venous Insufficiency.” Circulation. 2014;130:333-346. July 21, 2014.

    7. “Venous ulcers,” Medline Plus. U.S. National Library of Medicine. May 24, 2016.

    8. Stasis Dermatitis:



    The opinions and clinical experiences presented herein are for informational purposes only. Individual results may vary depending on a variety of patient-specific attributes and related factors. Dr. Raghu Kolluri has been compensated by Philips for his services in preparing and providing this material for Philips further use and distribution.


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